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These pathways synergistically interact with oestrogen signalling to facilitate the development of hormone-dependent malignancies by augmenting aromatase activity and decreasing sex hormone-binding globulin (SHBG) levels, resulting in increased levels of free oestradiol and androgen

These medications carry an FDA boxed warning for individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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