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Kidney Outcomes: A 2026 target trial emulation found SGLT2i superior to GLP-1 RAs for reducing the 5-year risk of CKD and acute kidney injury

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By reducing hunger and calorie intake, GLP-1 medications allow for gradual, sustainable weight loss without the need for drastic calorie restrictions or excessive exercise

For example, GLP-1s offer cardioprotective effects, likely mediated by improved endothelial function and reduced inflammation

Electrolyte balance : Some agents can affect sodium, potassium, or fluid balance, which is particularly risky in renal patients