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During RYGB, the stomach is divided to create a small gastric pouch (typically 15-30ml), which is then connected directly to the mid-small intestine, bypassing the remainder of the stomach and the duodenum

This might lead to less physical activity
Paroxetine inhibits CYP2D6 and may reduce tamoxifen effectiveness, so venlafaxine is preferred for breast cancer patients on tamoxifen