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It's critical because it: Minimizes side effects like nausea and GI discomfort Lets your body adjust to the medication Helps find your optimal therapeutic dose Most patients step up roughly every 4 weeks over a 1216 week schedule until reaching a maintenance dose which keeps side effects down while supporting results

The dual GIP/GLP-1 mechanism provides synergistic insulin secretion from pancreatic beta cells

Although Selonsertib was generally well tolerated with no safety concerns, none of the studies achieved their primary endpoint of an improvement in fibrosis without worsening of NASH (after 48 weeks of treatment)

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