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Injection site reactions : Localised redness, swelling, or discomfort at the injection site
Based on the strength of evidence and safety boundaries, a more rational clinical positioning is to reserve GLP-1RAs as an individualized tool for intensive metabolic optimization prior to ART in refractory PCOS individuals with high BMI and prior weight-loss failure
The most evidence-supported approach is optimizing nutrient levels before starting GLP-1 therapy: get baseline bloodwork for ferritin, vitamin D, zinc, and B12
Effective contraception should be used during dose adjustments and the washout period
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