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Individuals with poorly controlled diabetes (HbA1c 9% or 75 mmol/mol) generally experience larger absolute reductions compared to those with near-target values

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GI flare-ups are most likely during three predictable windows: the first week of starting Zepbound, the week immediately after every dose increase, and around week three of any new dose level when symptoms sometimes peak before tapering

The weekly injection, by contrast, does not fight digestion at all, so it delivers a steady dose over days

And certain spices turmeric, cinnamon, cayenne have demonstrated meaningful GLP-1 effects in human studies