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Male C57BL/6 mice (Jackson Laboratories) and male ob/ob mice (B6.Cg-Lep ob

effector concentration for half-maximum response) and maximal efficacy ( E max (%)) of peptides relative to the reference ligand Ex4 (Table 1)

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p -value 0.0030]), tirzepatide (RR 2.8997 [95% CI 2.0048, 4.1939