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4 Other than being on GLP-1s, higher risk patients include: those in the dose-escalation phase and those with upper GI symptoms (eg, nausea, vomiting, dyspepsia, abdominal distension, and abdominal discomfort/pain). 4 And obviously, other high-risk group includes patients with comorbidities associated with delayed gastric emptying (eg, poorly controlled diabetes, Parkinsons disease, bowel dysmotility) as well as those on other drugs that slow gastric emptying (eg, opioids, tricyclic antidepressants, marijuana, alcohol)

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Furthermore, investigations utilizing the GLP1 receptor antagonist exendin 939 have provided evidence that the glucoselowering effectiveness of DPP4is diminished when GLP1 signalling is eliminated [125, 126]

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G., Pozzi, A., Zent, R