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GLP-1 RAs act by stimulating insulin secretion in a glucose-dependent manner, inhibiting glucagon release, and slowing gastric emptying, which together improve overall metabolic control and reduce appetite (Nathan et al
The most frequently reported adverse effects are gastrointestinal in nature, including nausea, vomiting, diarrhea, constipation, and abdominal pain

Compounded weight-loss drugs are a growing problem for state regulators Last August, North Carolina began covering some federal Food and Drug Administration-approved GLP-1s for obesity treatment among some populations

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