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Semaglutide for weight loss: unanswered questions

Given the increasing interest in the potential use of incretins in cardiovascular diseases, conducting randomized controlled trials in this direction is warranted

The anti-inflammatory and antioxidant effects of GLP-1RAs observed in other organ systems may prevent damage in ocular tissues, leading to reduced risk of nonexudative age-related macular degeneration (AMD), exudative AMD, and primary open-angle glaucoma (POAG) compared to other diabetic medications (Figure 1)

Combined with topiramate (as Qsymia), results improve to 8-10% average weight loss

Limited Long-term Data : While short- to medium-term data are compelling, the long-term safety and efficacy profile over decades of treatment remains incompletely characterized