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Some outcomes are already supported by large trials

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Associations of sociodemographic characteristics, health factors, weight changes, and gastrointestinal adverse events with discontinuation and reinitiation outcomes were modeled using time-varying Cox proportional hazards regression models

GLP-1 receptor agonist therapy requires ongoing assessment and potential dose adjustments based on treatment response, tolerability, and evolving clinical needs
Becker RH, Stechl J, Steinstraesser A, Golor G, Pellissier F