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PlexusDx offers GLP-Squared (dual semaglutide and tirzepatide compound), which combines two GLP-1 mechanismsa different dual approach than mixing GLP-1 with SGLT2 inhibitors

Always consult with your healthcare provider before starting any new medication, particularly if you have IBS or other digestive conditions

A few mechanisms that don't reduce neatly to mesolimbic dopamine: (1) conditioned aversion, GLP-1 activation engages nausea/malaise circuits, so some of the reduction in substance use may reflect aversive conditioning rather than reward modulation per se

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18,19 In addition to being a peripheral incretin, GLP-1 is a central neuropeptide which is a cleavage product of the pre-proglucagon neurons produced in the nucleus tractus solitarius