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What This Means Practically If cardiovascular risk reduction is a priority (especially for someone with existing heart disease), semaglutide has the stronger evidence base right now

For people who have not yet started GLP-1 therapy and are deciding between the two medications, the semaglutide vs tirzepatide comparison page provides a detailed head-to-head analysis

To further verify the differences, subgroup-based stratified analyses and sensitivity analyses were conducted

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