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Individuals with a personal or familial history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should avoid this medication because of the potential risk of thyroid neoplasms observed in preclinical studies

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Excess abnormal body fat, especially visceral adiposity and ectopic fat, is a driver of cardiovascular (CV) disease (CVD)3,4,5, and contributes to the global chronic disease burden of diabetes, chronic kidney disease, cancer and other chronic conditions Again, no definition for excess abnormal body fat and visceral and ectopic fat exists at varying levels in people of all sizes

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