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Endocrinology (2008) 149(3):133849

Physiology of incretins in health and disease

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A meta-analysis of five randomised placebo-controlled trials of liraglutide in type 1 diabetes validated these findings and additionally demonstrated no association of liraglutide with severe hypoglycaemia or DKA [55]

Significant levels of liraglutide were found in the brain of mice 30 minutes and 3 hours after intraperitoneal injection, indicating that liraglutide could cross the BBB (130)