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A random effects model was selected to perform the meta-analyses, results were expressed as weighted mean differences for continuous outcomes and relative risks for dichotomous outcomes, both with 95% confidence intervals, and with I2 values and P values as markers of heterogeneity

Solid-Phase Peptide Synthesis (SPPS) of: A tetrapeptide extension (Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH) A C18-fatty acid linker with Glu-2xAEEA (PEG-based) Chemical Coupling of the components via NHS/DCC activation, followed by RP-HPLC purification and lyophilization