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With the addition of icodec, the curve shifts to the right, indicating that there is competitive binding for albumin between semaglutide and icodec leading to more free semaglutide in the presence of icodec at all HSA concentrations owing to the relatively stronger albumin binding properties of icodec

[14] [15] Some research suggests potential indirect metabolic benefits: as body composition changes with weight loss, there may be improvements in insulin sensitivity and glucose metabolism

Clinical data suggests combined therapy produces 15-22% weight reduction over 24 weeks versus 8-12% with GLP-1 alone, but metabolic adaptation still occurs

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