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Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3

Body has adapted almost no side effects

Lancet Diabetes Endocrinol 3(5):367381 van Bommel EJM, Muskiet MHA, Tonneijck L, Kramer MHH, Nieuwdorp M, van Raalte DH (2017) SGLT2 inhibition in the diabetic kidneyfrom mechanisms to clinical outcome

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The GLP-1 receptor agonist component increases insulin secretion and slows gastric emptying, which helps the patient feel full