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Santo MA, Riccioppo D, Pajecki D, Kawamoto F, de Cleva R, Antonangelo L, Maral L, Cecconello I

Frias JP, Deenadayalan S, Erichsen L, Knop FK, Lingvay I, Macura S, et al

Insulin secretion assays Insulin secretions in islets Purified islets were incubated in 3 mM glucose KRBH buffer for 1 hour at a shaking water bath at 37C

It belongs to a class of drugs called incretin mimetics, but unlike existing medications (semaglutide targets one hormone pathway, tirzepatide targets two), retatrutide activates three metabolic receptors : GLP-1, GIP, and glucagon

Patients who experience side effects, plateaus, or inadequate response on one medication can switch to another