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Ye Y, Liu X, Wu N, Han Y, Wang J, Yu Y, et al

GLP-1 plays several critical roles in glucose and appetite regulation: it stimulates insulin release from the pancreas, inhibits glucagon secretion to prevent excess glucose production, slows gastric emptying to moderate post-meal blood sugar spikes, and promotes satiety by acting on hunger centers in the brain (6)(23)

It's important to note that these medications carry a boxed warning for risk of thyroid C-cell tumors and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Within the GLP-1 RA + CKD group, eGFR reduced from 50.1 ml/min per 1.73 m 2 to 44.8 ml/min per 1.73 m 2 at 5 years

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