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One in five adults has taken a GLP-1 drug at some point, according to a November 2025 poll from health-care think tank KFF

Oral agents may be more acceptable to some patients, while others prefer the benefits of injectables despite the delivery method

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Thirst suppression is particularly problematic considering the drugs other side effects, such as vomiting and diarrhea, which cause dehydration, Daniels added

The semaglutide constipation and tirzepatide constipation resources cover management strategies for ongoing digestive issues, many of which apply during the transition period