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Central administration of GLP-1 in rats and mice stimulates the HPA axis and increases secretion of corticosterone, and this is accompanied by increased cFOS immunoreactivity in CRH-positive neurons in the PVN [668,698,814]

The Oral Semaglutide Treatment Effect in People with Obesity (OASIS) study was implemented in individuals with obesity or overweight associated with comorbidities comparing oral SMG (n = 320) versus placebo (n = 307) over 68 weeks [150]

Add back one food category every 3 to 4 days

5 Persistence and discontinuation Persistence with GLP-1 therapy has been a major concern

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