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Surprisingly, metformin prolonged the lifespan of mammals and decreased lung inflammation caused by COVID-19 in a mouse model of acute respiratory distress, possibly by blocking the activation of NLRP3 inflammasome through the inhibition of mitochondrial DNA synthesis (Xian et al., 2021)

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doi: 10.1089/thy.2008.0423

Below, we explain how retatrutide works inside the body, when effects tend to begin, and what the early clinical data tells us so far
