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Interestingly, exenatide in the LS does not impair anxiety-like behaviors or operant responding, which are key functions for cells within this region that indicate a fine tuning of GLP-1R action in this region

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Notably, GLP-1RAs benefit pain management through their neuroprotective and metabolic regulatory properties, such as inhibiting inflammation responses and oxidative stress, promoting -endorphin release and modulating several other crucial biological pathways