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One thing that I didnt find a lot of information about was their approach to helping make sure their patients are utilizing these medications alongside other healthy habits like strength training and a balanced, protein-forward diet (both of which I help my clients in the Simply Strong App with!)

It is approved for type 2 diabetes but is often used off-label for weight loss

The TRIUMPH-4 osteoarthritis data a reminder One thing worth flagging from TRIUMPH-4 (published December 2025), because it gets less coverage than the weight-loss numbers: in participants with obesity and knee osteoarthritis, retatrutide 12 mg produced an average 75.8% reduction in WOMAC pain scores , with more than one in eight participants ending the trial completely free of knee pain

These targeted treatments regulate key functions such as appetite control, metabolism, energy levels, and hormone balance

View Study [4]"MOTS-c modulates skeletal muscle function by directly binding and activating CK2" Kumagai H, Kim SJ, Miller B, et al., 2024 Finding: Researchers discovered that MOTS-c directly binds and activates the CK2 enzyme, which is required for its muscle-protective effects