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The trial was designed not only to test tirzepatide versus dulaglutide but also to assess the superiority of tirzepatide relative to an imputed placebo, the effect of which was derived from meta-analytic extrapolation of previous GLP-1RA trials [5]
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Other patients find that taking semaglutide before bed allows them to rest through the initial adjustment period, then wake up with appetite already reduced for the next day
doi: 10.1016/j.cell.2015.02.047 102 ZhangJ.ZhuS.MaN.JohnstonL
Some antihistamines, such as Allegra (fexofenadine)
