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This study investigated whether semaglutide (SMG) can counteract the disruption to the gut-heart-metabolic axis and associated myocardial injury caused by obesity
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Completion of the trials main phase is expected in September 2025, and the 52-week extension (in which participants and investigators remain blinded to treatment assignment) will continue to October 2026
Our analysis identified a calcium signaling bottleneck as the central explanation for the EVOKE biomarker-clinical disconnect why semaglutide reduced CSF tau and neuroinflammation markers by ~10% yet failed to slow cognitive decline on CDR-SB
