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The specific indicators of this improvement were: increased cardiac output, stroke volume, and peripheral muscle oxygenation

Besides lowering blood glucose, Lixisenatide improves cardiovascular health, delays stomach emptying, protects pancreatic beta-cells, and increases insulin messenger RNA (mRNA) expression and hormone release [237], [238]

1, 2011, and Jan

The currently ongoing SUMMIT trial (A Study of Tirzepatide in Participants With Heart Failure With Preserved Ejection Fraction and Obesity

While these studies suggest that GLP-1 influx into the brain might be a GLP-1R-independent process with passive diffusion of GLP-1 through the BBB [[750], [751], [752]], other studies suggest that uptake of liraglutide into the brain is GLP-1R-dependent [686,753]