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While the clinical evaluation of GLP-1MK-801 for weight loss awaits, efforts to broaden the scope of developing peptide-mediated targeting of ion channels are encouraged and should not be restricted to metabolic diseases

Oxyntomodulin is an endogenous peptide secreted by the enteroendocrine cells of the intestine in response to oral nutrients, which acts as an agonist at both GLP-1 and glucagon receptors [40]

Enzyme-linked immunosorbent assay for measuring active GLP-1 In 24-well plates, GLUTag cells were seeded at a density of 1.02.0 10 5 cells per well

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doi: 10.1016/j.ando.2022.12.423