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5 FDE is more commonly associated with oral medications

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Hind Paw Cold Allodynia Test The hind paw cold allodynia test is employed to assess cold thermal sensitivity by assessing the withdrawal response of the rats hind paw when it is delicately immersed in ice-cold water at 4 1 C

This risk was first identified in long-term rodent carcinogenicity studies, where exposure to liraglutide and semaglutide led to dose-dependent C-cell hyperplasia and tumors

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Maridas DE, Rendina-Ruedy E, Helderman RC, DeMambro VE, Brooks D, Guntur AR, Lanske B, Bouxsein ML, Rosen CJ