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WD increased inflammation in the amygdala and ventral hippocampus in a sex-specific manner and GE2 reduces inflammation in the hippocampus and amygdala dependent on diet and sex, respectively In the present study, we found sex- and site-specific increases in inflammation in response to WD exposure, in which males presented with elevated inflammation in the ventral hippocampus, whereas females presented with increased inflammation in the amygdala

While the exact dose-response relationship for these effects is less clearly established than for GI symptoms, clinical pharmacology suggests that any side effect mediated by GLP-1 and GIP receptor activation could intensify with higher drug exposure

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