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The risks depend on the contraindication

GLP-1 medications address the underlying metabolic factors that drive weight gain, so emphasizing metabolic health rather than appearance-based goals often resonates better with physicians and strengthens the clinical rationale for treatment

It should be prescribed within specialist weight management services as part of a programme including dietary, physical activity and behavioural support

However, the question remains as to how these drugs are used in patients with a diagnosis of cancer

For persistent constipation without red flags, pharmacological management may be appropriate