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While the FDA provides guidelines to manage drug shortages, including temporary allowances for compounded GLP-1 medications, this does not eliminate safety risks

Additionally, it was demonstrated that the long-acting triagonist protected against Parkinson disease in mice by attenuating microglial activation and inflammation in the specific brain regions [31]

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Therefore, the development of novel drug delivery systemswhether by enhancing BRB penetration or through direct ocular targeting (e.g., long-acting intravitreal formulations)is a critical and rate-limiting step for the clinical translation of these agents