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The influence of GLP-1-based therapies on alcohol addiction appears to be even more pronounce in patients after bariatric surgery where the risk of alcohol addiction is significantly higher than in generral population As always, more data in particular from randomized studies is needed Based primarily on these two excellent papers: #glp1 #semaglutide #tirzepatide #alcohol #addiction

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Here authors report the cryo-EM structure of GLP-1R bound to an ago-allosteric modulator in complex with heterotrimeric Gs which offers insights into the molecular details of ago-allosterism.