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What you need to focus on is safe and predictable outcomes and a customized plan based on what you need for your health

Had we assessed risk of bias for less objective outcomes, such as participant-reported gastrointestinal adverse events, overall risk of bias for such outcomes in these trials might have been deemed of some concern

Although the absolute risk remains relatively low, studies show a modest but consistent increase in gallstones and cholecystitis among treated patients compared to placebo

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Contributor Information Paul Dimitri, The Department of Paediatric Endocrinology, Sheffield Children's NHS Foundation Trust, Sheffield, S10 2TH, UK