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Usage began before the FDA label-update cutoff for the relevant injury (March 2022 for Ozempic gallbladder claims, January 2024 for Mounjaro pulmonary aspiration, January 2025 for Ozempic severe GI reactions)

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Curcumin and its electrophilic oxidation products react with nucleophilic thiols in a Michael-type addition forming a covalent adduct (17)

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