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Protocol: Creatine: 5g daily, post-training on workout days Protein: 1.6-2.0g per kg body weight Training: Sport-specific, maintained as close to pre-tirzepatide levels as possible Additional: HMB (beta-hydroxy beta-methylbutyrate) at 3g daily may provide additional anti-catabolic support Monitoring: Performance metrics specific to sport For athletes, creatine is non-negotiable during tirzepatide use

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While many other treatments, like semaglutide, focus solely on GLP-1 receptors, tirzepatide activates both GLP-1 and GIP receptors, creating a more comprehensive effect on weight loss

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Whatever the reason, remaining at 2.5 or 5 mg when your body has adapted to that dose means the medication is no longer providing sufficient appetite suppression