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that is, those with established atherosclerotic CVD, CKD or both

Further investigation shows that a GIP analog diminished the differentiation and bone resorptive efficacy of human osteoclasts (Mabilleau et al., 2016), and treatment of human osteoclasts with GIP analogs resulted in a diminution of gene expression pertaining to distinctive markers of osteoclasts as well as a decline in the quantity of nascent osteoclasts (Gobron et al., 2020), suggesting a direct influence of GIP on human osteoclasts

Although the weight might be gone, so is the tissue that would have helped keep that loss and continue burning calories effectively

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