why doesn't semaglutide work for some people & Tirzepatide Why Semaglutide Isn't Working: 6
Description
A possible mechanism: GLP-1s appear to dampen dopamine-mediated reward responses , which may be helpful for cravings, but could also blunt some forms of desire, including sexual

GLP-1 6 5.3% , 8%
Note* - This Guidelines+ Monographs for semaglutide (Ozempic) is current as of April 2025

What it does do is increase resting heart rate by 1 to 4 BPM through direct action on GLP-1 receptors in the heart sinoatrial node

Results depend on health history, provider approval, treatment plan, adherence, and individual factors