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GLP-1 receptor agonists represent a breakthrough for managing type-2 diabetes and obesity, offering metabolic benefits across multiple organ systems

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Since patients may experience fatigue with GLP-1 RAs, start with modest goals and build up to 150 min/wk of moderate intensity activity or 75 min/wk of vigorous activity

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Among regular drinkers, consumption plummeted from 23.2 to 7.8 units per week a 68 percent reduction, which Professor le Roux noted is comparable to that achieved by nalmefene, a drug used to treat alcohol use disorder in Europe. The potential for these weight loss drugs to reduce alcohol consumption could yield additional public health and economic benefits
