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[176].Novo Nordisk A/S, Novo Nordisk Annual Report 2011, 2012

Based on these two signal pathways, insulin enhances PDA development through mediating metabolic reprogram, crosstalk with IGF-1, strengthening drug resistance, and stimulating tumor microenvironment (inflammation, fibrosis, and neo-angiogenesis) formation

Because of these effects, GLP-1 receptor agonists like Semaglutide are used in the treatment of type 2 diabetes and obesity

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Overall, preclinical and phase 1 data support that the primary mechanism for weight reduction by tirzepatide is regulation of appetite and decreases in food cravings and food intake, with increased lipid metabolism [76]