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(14), who reported that GLP-1Rs in the PVN, but not the ARC, transduce the acute anorectic effects of intracerebral GLP-1 in rats

The key difference is that Wegovy works by targeting a single hormone receptor (GLP-1), while Mounjaro targets both GLP-1 and another hormone receptor called GIP, which may enhance its effects

It remains an investigational medicinal product (IMP) and is therefore not available for prescription or purchase in the United Kingdom outside of approved clinical trials