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Safety and Clinical Management Safety trials of GLP-1 RAs, including liraglutide, tirzepatide, and semaglutide (oral or subcutaneous), indicate that the most common adverse events (AEs) of treatment are mild to moderate gastrointestinal including nausea, vomiting, diarrhea, constipation, dyspepsia, and decreased appetite

Such measures dont necessarily translate to slowing aging itself, and the paper is undergoing peer review, according to one of its authors

While the hazard ratio (HR) was 1.60, the absolute numbers were small (3% vs 0.5%)

More than half (52%) of GLP-1 users described their eating habits as "mindful", saying they are increasingly guided by hunger cues rather than established routines or restrictive dieting practices

This often leads to reduced calorie intake