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PAPLA3 is one of the members of the patatin-like phospholipase family that have been identified as being closely associated with the development of MASLD (97,98), PNPLA3 was found to be expressed mainly in the liver and adipocytes, with non-specific TG lipase and acylglycerol transacylase activities involved in TG hydrolysis in hepatocytes

For example, exendin-4 lowers very-low-density lipoprotein cholesterol (VLDL-C) and LDL-C in animal models by reducing hepatic sterol regulatory element-binding protein 2 (SREBP2) levels and cholesterol absorption (88)

doi: 10.3389/fimmu.2023.1283792 95 MowersEESharifiMNMacleodKF

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