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Triagonists (for example GLP-1/GIP/glucagon) are currently in pre-clinical or early clinical development

There is no doubt that GLP-1 medications for weight loss are changing the game in terms of how we view and treat obesity, weight loss and even plastic surgery

Using an integrated ligand and structure-based virtual screening pipeline, explicitly combining complementary ligand-based descriptors, multi-fingerprint similarity, electrostatic similarity, pharmacophore modeling, and multi-conformation docking under a consensus-driven selection strategy, we were able to identify three chemically distinct classes of GLP-1R agonist candidates: GQB47810, a non-peptidic molecule
In this randomized clinical trial ...