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Furthermore, these therapies have been shown to reduce the activation of microglial cells, key immune cells that play a significant role in triggering chronic pain in the central nervous system [36]

cAMP: cyclic adenosine monophosphate

Topiramate is an antiepileptic drug, and this class carries an FDA warning about increased risk of suicidal thoughts and behavior

It found that these drugs may slightly increase the chance of getting gallstones (cholelithiasis) and acid reflux (GERD)

Firstly, there was no head-to-head CVOT directly comparing these antidiabetic drug classes
