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The guidelines have changed, too the ADA recommends offering AID to anyone with type 1 diabetes, even early after diagnosis

This triple mechanism distinguishes it from existing agents such as semaglutide (a GLP-1 agonist) or tirzepatide (a dual GIP/GLP-1 agonist)

Furthermore, in this study, we utilized male rats for the investigation, primarily based on the consideration that the stable long-term testosterone levels in males lead to smaller fluctuations in physiological indicators, thereby facilitating the standardization of experimental results ( The pharmacodynamic results of CGA from this study also strongly suggest that to maintain its effective therapeutic concentration in vivo , it may be necessary to develop sustained-release or targeted delivery systems (e.g., nanoparticles, liposomes, transdermal patches, etc.) to counteract its rapid clearance, reduce dosing frequency, and improve patient compliance