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Lancet 2023;402:61326.PubMed 94

GLP-1RAs are a relatively new class of injectables that are effective at reducing HbA 1c , have a low risk of hypoglycaemia when given as monotherapy or in the absence of sulphonylureas (SU) or insulin, and have the potential for weight losskey considerations when treating a typical obese patient with T2DM [4]

Non-GLP-1 group (79,699 people): 19 cases of NAION

A phase 2, 16-week, open-label study in 18 subjects ranging from 6 to 40 years of age results in a mean BMI reduction of 18% in those younger than 18 years, and 6% for those 18 years or older, accompanied by significant reduction of hunger scores (127)