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A new umbrella review reveals how GLP-1 therapies shape cardiovascular, renal, and metabolic outcomes in type 2 diabetes while highlighting drug-specific advantages and the need to manage gastrointestinal risks

Intravenously administered GLP-1 has a biological half-time of approximately only 12 min

Historically, adverse effects of pharmacologic interventions for obesity have generated concern over the use of pharmaceuticals [33]

Consistent with the FAP-based approach, stimulation with PF-06882961 for 30 minutes triggered marked intracellular accumulation of GFP-GLP-1R, which was reversible following a 2-hour washout period