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Patients should be advised to contact their GP or NHS 111 if they experience: Red flag symptoms requiring urgent assessment: Severe, persistent abdominal pain , particularly if in the upper abdomen and radiating to the back (may indicate pancreatitis) Severe abdominal pain and distension with vomiting and inability to pass wind or stools (may indicate bowel obstruction) Persistent vomiting , particularly if unable to keep down fluids, raising concerns about dehydration Abdominal distension with rigidity or extreme tenderness on palpation Blood in vomit or stools (melaena or haematochezia) Unintentional weight loss beyond expected therapeutic effects Fever accompanying abdominal symptoms , which may suggest infection or inflammation Right upper quadrant pain or jaundice (yellowing of skin/eyes), which may indicate gallbladder disease For severe symptoms, call 999 or go to A&E immediately

The AGA and ACG provide evidence-based guidelines emphasizing treat-to-target strategies, with objective monitoring through endoscopy, cross-sectional imaging, and biomarkers (C-reactive protein, fecal calprotectin) to assess mucosal healing and optimize outcomes

Content Updated: March 13, 2026 Key takeaways Microdosing with semaglutide involves administering smaller doses than the standard amount

Assuming it is approved by the UK's Medicines and Healthcare products Regulatory Agency, it is anticipated to be available late 2026 to early 2027